is it possible to completely destroy something?

just what the title says, is it possible to completely destroy something even its subatomic particles to where it no longer exists in any form/ is nothing?

i know we as humans can’t do this but what about the heat death of the universe/ the end of the universe in general? or any other space event that happens? is it ever possible to completely break something down to where instead of turning into something else it’s completely gone?