Alcoholism
I know it may be controversial but im suprised that alcoholism isnt a trait in the game. Theres a reason that in real life even in the most crazy social emergencies the liquor stores stay open. Because most would face serious consequences or death at stopping cold sober. This seems like a rich area for perk positives/negatives. You could even bring your toon out of it for the exchange of withdraw symptoms for like a month or two.
I understand this might hit too close to home for some.