Am I the only one who HATES cefdinir?
I keep seeing cefdinir be given from PCPs, urgent care, the ED, or on discharge and it’s mildly infuriating to me. What’s more, when I’m trying to call in a 2nd/3rd gen cephalosporin for one of my PCN-adverse patients, the only thing most pharmacies seem to keep in stock is cefdinir.
From an incredibly early point in my training, I was firmly dissuaded from ever ordering or prescribing cefdinir for anything other than a bloodstream infection because it has a terrible Vd—especially in adults (bad PK/PD in general from what I understand)—and thus does not penetrate the tissues well at all. What’s more, for infants with AOM, it can actually bind to the iron in their formula preventing the absorption of an already questionable antibiotic.
Price, marketing, and/or general lack of awareness are the only things I can think of for this trend, but cefpodoxime—which to me seems better in almost every way—is barely more expensive and Ceftin (RIP) was on par.
While I do feel strongly about this medication, I am 100% open to the idea that I’m missing something or just flat out wrong in my understanding of pharmacokinetics so if anyone can shed some light on this for me I would definitely appreciate it.
Edit: to clarify, I am definitely not arguing that cefdinir should ever be used for a BSI (again I hate it), I was more saying that whatever amount does get absorbed into your body, it’s staying in the bloodstream bc of its terrible Vd
Edit 2: https://shmpublications.onlinelibrary.wiley.com/doi/abs/10.1002/jhm.13415