Pedalboard platform - High Gain pedals into a clean amp pedal.

Hey hivemind.

So I have a pretty hefty board. And am currently running into an Orange Micro Dark.

However, for a couple of reasons, I am wanting to move to an amp emulation and IR in a box setup.

I like to get most of my drive from pedals these days. Current drive setup is:

Horizon Precision Drive -> BD-2 -> OK Doomer -> EQD Life

I have been looking at the Strymon Iridium, UAD Dream '65, TC Electronic Combo '65 or Jim's 45 and Nux Amp Academy. Possibly the boss IR-2 as well.

Does anyone have experience with running high gain pedals into any of these? How do they take other pedals before and after?