Bruylants reaction developments

High bees,

the Bruylants reaction is for us mostly known by the synthesis of Pcp via the a-aminonitrile intermediate. Cyanides are hard to get for some of us and anhydrous sulfonic acids are harder to aquire too. But nowhere on the archives we read, the possible use of pyrazoles/triazoles instead of cyanide is mentioned. The use of benzotriazole is said to be produce less side reactions/ toxic products.

Ive found 2 papers synthing pcp via the benzotriazole leaving group. The yield in both papers were around ~72%. Benzotriazole is easy to get and not that expensive, and it's also possible to recycle it. Only drawbacks are the use of a dean and stark trap, the use of 4mol equivalents grignard reagent and the prolonged reaction time.

"The Bruylants and related reactions"

Is a overview article easy to find as pdf.

Will post my bruylants trials in the near future.

Keep flying bees