What decision are you unable to make? Or dialogue choice? [Spoilers]

I've been able to do most things, but not ask Tabitha to sacrifice for Charles Shaw Jr. Also, it's hard to pick the mean lines in this game 😂 One I refuse to do is when the doctor is seeing Rosalina and you can say "are you poisoning her now too." Reminds me of past rpgs that were savage like the older Fallouts