APM solutions for React/Http

I want to tap into the hive mind to get suggestions for Application Performance Monitoring services that can support React/Http based applications. I've looked at Newrelic (and have used in the past) and Datadog (which is our preference). It seems most services that support PHP assume the application is running behind FPM and cannot work on an eventloop. Are there any out there that support this natively or with a minimum of configuration/workarounds? Has anyone run Datadog with a React/Http app before?